Key result
Systemic lupus erythematosus linked to significantly impaired endothelial function versus healthy controls.
Why the study?
Do female patients with systemic lupus erythematosus have impaired endothelial function compared to healthy controls?
Case-Control (n=58)
Do female patients with systemic lupus erythematosus have impaired endothelial function compared to healthy controls?
Absolute Event Rate: 5.6% vs 8%
p-value: p=0.001
Female patients with SLE have significantly impaired endothelial function compared to healthy controls, although this impairment did not correlate with the development of cardiovascular or other organ damage over a 5-year follow-up.
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SLE-associated endothelial dysfunction observed here; leaves open its prognostic value for cardiovascular outcomes beyond 5 years.
Piper et al. (2007) conducted a case-control in Systemic lupus erythematosus (n=58). Systemic lupus erythematosus vs. Healthy controls was evaluated on Endothelial dependent vasodilatation (EDD) (p=0.001). Systemic lupus erythematosus was associated with significantly impaired endothelial function compared with healthy controls (median EDD 5.6% vs 8.0%; P=0.001).
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