Key result
Systemic lupus erythematosus was associated with pathological brachial artery reaction on reactive hyperemia testing in 48% of patients, all of whom had renal disease.
Why the study?
This study aimed to characterize the features of endothelium-dependent regulation of vascular tone in patients with systemic lupus erythematosus.
Case-Control (n=85)
Answers are grounded in this paper and cite their sources.
Endothelial assessment may flag vascular risk in SLE; leaves open prospective outcome prediction or therapeutic targeting.
Objective. To study features of endothelium-dependent regulation of vascular tone in pts with systemic lupus erythematosus (SLE). Material and methods . 52 SLE pts aged 17 to 52 years (mean age 34±1,3 years) and 33 healthy volunteers of control group aged 22 to 50 years (mean age 32±2 years) were examined. Mean disease duration was 7,4+0,4 years. 4% of pts had acute, 27% - subacute, 69% - chronic course of the disease. 29% of pts had minimal, 50% - moderate and 21% - high activity. D. Celemajer ultrasonic method was used to assess endothelial function. Results. In healthy persons reactive hyperemia test showed increase of vascular lumen in systole and diastole so as decrease of relative systolic increase. SLE pts had increase of vascular wall rigidity, ultrasonic signs of brachial artery changes. Reactive hyperemia test at 15th second showed normal reaction of brachial artery in 38%, pathological - in 48% and indefinite - in 14% of pts. All pts with pathological reaction and only 40% of pts with normal reaction had renal disease.
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Husainova et al. (2005) conducted a case-control in Systemic lupus erythematosus (n=85). Systemic lupus erythematosus vs. Healthy volunteers was evaluated on Pathological brachial artery reaction at 15 seconds on reactive hyperemia test. Systemic lupus erythematosus was associated with pathological brachial artery reaction on reactive hyperemia testing in 48% of patients, all of whom had renal disease.
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