Key result
Anger induction cuts coronary flow ~65% in dogs with critical stenosis via increased vascular resistance.
Why the study?
The influence of anger on myocardial blood flow in normal and compromised coronary circulations was not well characterized.
Does anger induction alter myocardial blood flow and induce ischemia in dogs with and without critical coronary stenosis?
Comparison
Anger state induced by social challenge vs baseline preanger state
Design
Preclinical experimental study with coronary stenosis model
Follow-up
2 to 4 minutes post-anger
Authors
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Anger may provoke ischemia in stenotic vessels; hypothesis-generating for emotional triggers in human CAD.
Does anger induction alter myocardial blood flow and induce ischemia in dogs with and without critical coronary stenosis?
p-value: p=<.001
Anger induces delayed myocardial ischemia and significant reductions in coronary blood flow in a canine model with critical coronary stenosis.
Verrier et al. (1987) studied myocardial ischemia (n=14). Anger induction vs. Baseline (preanger levels) was evaluated on Coronary arterial flow (p=<.001). In dogs with critical coronary stenosis, anger induction significantly reduced coronary arterial flow to 35% of baseline (p<0.001) and increased coronary vascular resistance (p<0.002).
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