Key result
Highest quartile of visceral fat mass index linked to ~485% higher diabetes risk versus lowest.
Why the study?
Visceral fat mass index is linked to insulin resistance and cardiovascular impairment, but its relationship with diabetes and vascular complications needed evaluation.
Is higher visceral fat mass index associated with increased prevalence of diabetes and cardiovascular disease in adults?
Cross-Sectional (n=4,847)
Yes
Is higher visceral fat mass index associated with increased prevalence of diabetes and cardiovascular disease in adults?
Higher visceral fat mass index is strongly associated with an increased prevalence of diabetes and cardiovascular disease, highlighting the importance of visceral adiposity in cardiometabolic risk.
Association with higher diabetes prevalence supports visceral fat assessment in risk stratification; leaves open causality and CVD implications pending longitudinal data.
Background: Visceral fat mass index (vFMI), a key visceral obesity marker, is linked to insulin resistance and cardiovascular impairment. This study examined the relationship between vFMI, people living with diabetes, and its vascular complications. Methods: Data from NHANES (2011–2018) were used, including participants aged 18 years and older. Multivariable logistic regression models examined associations between vFMI and diabetes, diabetic nephropathy (DN), and cardiovascular disease (CVD). Result: A total of 4,847 participants were included, comprising 2,469 (50.9%) males and 2,378 (49.1%) females, with a mean age of 40 years. The prevalence of diabetes, DN, and CVD was 11.6% (567), 2.8% (136), and 4.3% (208), respectively. Participants in the highest vFMI quartile had a markedly higher risk of diabetes [odds ratio (OR): 5.85, 95% confidence interval (CI): 3.25 to 10.55], DN (OR: 2.84, 95% CI: 0.89 to 9.08), and CVD (OR: 2.55, 95% CI: 1.10 to 5.93) versus the lowest quartile. Nonlinear regression identified critical thresholds for log-transformed vFMI, beyond which risks sharply increased: 0.252 for diabetes and 0.241 for DN. Subgroup analysis showed stronger associations in younger participants (≤40 years), those with lower triglyceride levels, and those with higher β-cell function. Conclusion: Higher vFMI correlates with greater prevalence of diabetes and related complications, indicating that visceral fat plays a critical role in their development.
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Wang et al. (2026) conducted a cross-sectional in Diabetes and vascular complications (n=4,847). Visceral fat mass index (vFMI) vs. Lowest vFMI quartile was evaluated on Diabetes (OR 5.85, 95% CI 3.25 to 10.55). Being in the highest quartile of visceral fat mass index was associated with a markedly higher risk of diabetes compared to the lowest quartile (OR 5.85; 95% CI 3.25-10.55).
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