Key result
Untreated mild essential hypertension linked to increased lipid peroxidation and nitric oxide metabolites.
Why the study?
Previous studies have shown inconsistent data regarding oxidative stress status and nitric oxide metabolites in essential hypertension.
Observational (n=25)
Untreated mild essential hypertension is associated with increased lipid peroxidation and nitric oxide metabolites, suggesting an underlying inflammatory and oxidative stress state.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications for mild hypertension; hypothesis-generating for oxidative stress in larger prospective studies.
Many papers have showed non univocal data about oxidative stress status and nitric oxide metabolites in essential hypertension. Considering this preamble we examined the total antioxidant status (TAS), the lipid peroxidation (LP), expressed as thiobarbituric acid-reactive substances (TBARS), the stable end products of nitric oxide (NOx) and LP/NOx ratio in 25 subjects with untreated mild essential hypertension. The obtained data show a significant increase in TBARS (p < 0.001) and NOx (p < 0.001) in hypertensives and no variation in TAS and in TBARS/NOx ratio. None of these parameters was statistically related to the metabolic parameters or to the blood pressure values. The high level of lipid peroxidation observed in this group of hypertensives suggests the timely and specific employment of antihypertensive and antioxidant agents while the NOx increase seems to confirm the inflammatory status accompanying this clinical condition.
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Caimi et al. (2010) conducted an observational in Mild essential hypertension (n=25). Untreated mild essential hypertension vs. Normotensive controls (implied) was evaluated on Lipid peroxidation (TBARS) and nitric oxide metabolites (NOx) (p=<0.001). Untreated mild essential hypertension was associated with a significant increase in lipid peroxidation (p < 0.001) and nitric oxide metabolites (p < 0.001).
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