Key result
Essential hypertension in men is linked to ~18% lower total antioxidant status, dyslipidemia, and hyperuricemia.
Why the study?
Hypertension coexists with an imbalance in antioxidants and lipid profile, but the relationship between antioxidant status, oxidative stress, and lipid profile in hypertensive men requires evaluation.
Case-Control (n=96)
No
Absolute Event Rate: 589.73% vs 716.67%
p-value: p=<0.001
Essential hypertension in men is associated with increased oxidative stress, hyperuricemia, and dyslipidemia, alongside a depleted antioxidant defense system.
Supports oxidative stress link in male hypertension; hypothesis-generating and should not yet alter practice.
Hypertension is a major health burden and coexists of with imbalance in antioxidants and lipid profile.This study is done to evaluate the total antioxidant status and oxidative stress like Malondialdehyde (MDA), catalase, superoxide dismutase (SOD), uric acid and correlate with lipid profile among hypertensive men.Significant increase in MDA, uric acid and dyslipidemia was found among hypertensive men.Also total antioxidant status and other antioxidants like SOD, catalase was found to be decreased in hypertensive men.Hence it is concluded that lipid peroxidation occur in hypertension which leads to endothelial dysfunction, renal blood flow alteration and tissue damage.As a result of which dyslipidemia, hyperuricemia and decrease in anti oxidants are seen.Hence decrease in antioxidants is a useful marker for antioxidant therapy to prevent organ damage among hypertensive.
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N et al. (2013) conducted a case-control in Essential hypertension (n=96). Essential hypertension vs. Normotensive controls (BP ≤ 120/80 mmHg) was evaluated on Total antioxidant status (TAS) (p=<0.001). Essential hypertensive men exhibited significantly decreased total antioxidant status (589.73 vs 716.67, p<0.001) alongside increased dyslipidemia and hyperuricemia compared to normotensive controls.
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