Key result
Prehypertension and stage I/II hypertension were associated with significantly lower antioxidants and higher oxidative stress by-products like TBARS and CRP compared to normotensives (P<0.05).
Why the study?
Do Indian patients with various stages of hypertension have altered oxidative stress byproducts and antioxidant activities compared to normotensives?
Observational (n=80)
Do Indian patients with various stages of hypertension have altered oxidative stress byproducts and antioxidant activities compared to normotensives?
p-value: p=<0.05
Elevated blood pressure is strongly associated with increased oxidative stress and reduced antioxidant activity, suggesting a potential role of oxidative stress in hypertension pathogenesis.
Supports oxidative stress hypothesis in hypertension but should not change practice; leaves open causality and need for prospective trials.
In humans, hypertension is considered a state of oxidative stress that can contribute to the development of atherosclerosis and other hypertension-induced organ damages. The objective of this study was to evaluate oxidative status, antioxidant activities, and oxidative stress by-products among Indian patients with various stages of hypertension. Lipid profile, enzymatic and non-enzymatic antioxidants, lipid peroxidation as thiobarbituric acid reactive substances (TBARS), C-reactive protein, electrolytes, and minerals were analyzed in the blood of newly diagnosed prehypertensives, stage I and II hypertensives (n = 20 in each group) and were compared to their age-matched normotensives. Elevated levels of lipid profile (except high density lipoprotein cholesterol [HDL-C]) were observed in stage I and II hypertensive patients. Enzymatic and non-enzymatic antioxidants were significantly (P < 0.05) lower, while TBARS and C-reactive protein were higher in prehypertensives, and stage I and II hypertensives. Significant (P <0.05) changes were also observed in the plasma Na(+) and K(+) concentrations among the hypertensive groups. Serum levels of zinc, copper, and magnesium were significantly (P < 0.05) lower in prehypertensives, and stage I and II hypertensives as compared to normotensives. The study indicated a strong association between blood pressure (BP) and oxidative stress-related parameters and suggests a possible role of oxidative stress in the development of elevated BP.
No takes yet. Share an insight, caveat, or question.
Raman et al. (2011) conducted an observational in Hypertension (n=80). Hypertension (prehypertension, stage I, and stage II) vs. Normotension was evaluated on Oxidative status, antioxidant activities, and oxidative stress by-products (p=<0.05). Prehypertension and stage I/II hypertension were associated with significantly lower antioxidants and higher oxidative stress by-products like TBARS and CRP compared to normotensives (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: