Key result
CD31 and CD34 consistently stain myxoma cells, suggesting widespread endothelial differentiation.
Why the study?
Vascular endothelial cells are antigenically heterogeneous, necessitating the use of multiple immunohistochemical markers to identify endothelial origin cells in surgical pathology of left atrial myxomas.
Case Report (n=6)
Left atrial myxoma cells show more widespread endothelial differentiation than previously recognized, with differences in marker expression likely reflecting maturation status.
Answers are grounded in this paper and cite their sources.
Does not inform myxoma management; leaves open the role of endothelial differentiation in tumor biology.
Vascular endothelial cells are antigenically heterogeneous and therefore it has been recommended that a range of immunohistochemical markers is employed to show the presence of cells of endothelial origin in surgical pathology. In this study we applied three monoclonal antibodies--to factor VIII-related antigen, JC70 (CD31), QBend 10 (CD34)--and Ulex europaeus agglutinin type 1 lectin (UEA-1), to six consecutive cases of left atrial myxoma. We found that JC70 and QBend 10 consistently stained myxoma cells in all their different growth patterns contrasting with factor VIII-related antigen expression and UEA-1 binding which were restricted to areas which showed morphological evidence of vascular differentiation. These findings suggest that the constituent cells of atrial myxomas show more widespread endothelial differentiation than has previously been recognized and that differences in immunohistochemical staining may reflect the maturation status of these cells.
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Farrell et al. (1996) conducted a case report in Left atrial myxoma (n=6). Immunohistochemical staining (factor VIII-related antigen, CD31, CD34, UEA-1) was evaluated on Immunohistochemical staining patterns. Immunohistochemical staining with CD31 and CD34 consistently stained myxoma cells across all growth patterns, suggesting more widespread endothelial differentiation than previously recognized.
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