What is the clinical evidence from this study?

Study design: Cohort. Population: Isolated mitral valve replacement (n=151). Intervention: Mitral valve replacement with a bioprosthesis. Primary outcome: Bioprosthesis dysfunction.

What does this research mean for the field?

Mitral valve replacement with a bioprosthesis in patients aged 50 to 65 years results in high rates of bioprosthetic dysfunction, indicating that bioprosthetic valve use should be limited in this age group. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate long-term survival, valve durability, and complication rates in patients aged 50 to 65 years undergoing isolated mitral valve replacement with a bioprosthesis.

March 1, 1998Asian Cardiovascular and Thoracic Annals

Mitral Valve Replacement with Bioprosthesis in Age Group Fifty to Sixty-Five Years

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Key result

Bioprosthetic MVR in patients aged 50 to 65 is linked to ~5% annual valve dysfunction.

n=151

Why the study?

The outcomes and complication rates after mitral valve replacement with bioprostheses in patients aged 50 to 65 years were not well characterized.

What are the long-term outcomes and complication rates of isolated mitral valve replacement with a bioprosthesis in patients aged 50 to 65 years?

Population

151 patients aged 50 to 65 years undergoing isolated mitral valve replacement

Comparison

Mitral valve replacement with bioprosthesis

Design

Cohort study

Follow-up

Mean 4.34 ± 2.53 years (range 2 months to 10.9 years)

Authors

SKSalih Fehmi KatırcıoğluMinistry of Health BYBirol YamakMedical Park Gaziantep Hospital TUTulğa UluşTürkiye Yüksek İhtisas Hastanesi

Discussion

Member takes

Implication

May support limiting bioprosthesis use in this age group; leaves open optimal valve choice pending randomized data.

Key Points

To evaluate long-term survival, valve durability, and complication rates in patients aged 50 to 65 years undergoing isolated mitral valve replacement with a bioprosthesis.
Retrospective cohort analysis of 151 patients aged 50 to 65 years receiving isolated bioprosthetic mitral valve replacement between 1982 and 1990.
Cumulative follow-up totaled 527.6 patient-years, with a mean duration of 4.34 ± 2.53 years (range: 2 months to 10.9 years).
Hospital mortality was 10.6% (16/151), late mortality was 2.65% per patient-year (14/151), and 10-year actuarial survival was 78.5%.
Bioprosthesis dysfunction occurred at 5.11% per patient-year (27 patients; 26 required reoperation), with a 10-year freedom from bioprosthesis dysfunction of 56.6%.
Thromboembolic events occurred at 0.75% per patient-year (10-year freedom: 95.8%), paravalvular leaks at 0.37% per patient-year, and total valve-related complications at 6.44% per patient-year (10-year freedom: 49.6%).

Study Design

Type

Cohort (n=151)

Structured PICO

What are the long-term outcomes and complication rates of isolated mitral valve replacement with a bioprosthesis in patients aged 50 to 65 years?

Population

151 patients aged 50 to 65 years who underwent isolated mitral valve replacement with a bioprosthesis, followed for a mean of 4.34 years.

Exposure

Isolated mitral valve replacement with a bioprosthesis

Outcome

Hospital mortality, late mortality, bioprosthesis dysfunction, thromboembolic complications, and overall survivalhard clinical

The high rate of bioprosthesis dysfunction in patients aged 50 to 65 years undergoing mitral valve replacement suggests that bioprosthesis use should be limited in this age group.

Cite This Study

Katırcıoğlu et al. (1998) conducted a cohort in Isolated mitral valve replacement (n=151). Mitral valve replacement with a bioprosthesis was evaluated on Bioprosthesis dysfunction. Mitral valve replacement with a bioprosthesis in patients aged 50 to 65 years resulted in a high rate of bioprosthesis dysfunction (5.11% per patient-year), suggesting its use should be limited.

synapsesocial.com/papers/6aa9f25c2f1eb85158fc95a3 https://doi.org/10.1177/021849239800600105

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Mitral Valve Replacement with Bioprosthesis in Age Group Fifty to Sixty-Five Years

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Mitral Valve Replacement with Bioprosthesis in Age Group Fifty to Sixty-Five Years

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider