Key result
AQ-A39 reduces heart rate and increases subendocardial blood flow in dogs after acute coronary occlusion.
Why the study?
Does AQ-A39 (falipamil) improve coronary collateral blood flow in anesthetized dogs following acute LAD occlusion?
Does AQ-A39 (falipamil) improve coronary collateral blood flow in anesthetized dogs following acute LAD occlusion?
The bradycardic agent AQ-A39 increases coronary collateral perfusion in a canine model of acute myocardial ischemia, an effect driven by heart rate reduction.
Answers are grounded in this paper and cite their sources.
Bradycardic effects may enhance collateral perfusion in acute models; extends preclinical observations but leaves open human translation.
The effect of two doses (0.5 and 1.0 mg/kg i.v.) of a new specific bradycardic agent, AQ-A39 (5,6-dimethoxy-2-[3- [( alpha- (3,4,-dimethoxy)phenylethyl]methyl-amino)propyl]phthalimidine hydrochloride), on three indices of collateral function--retrograde pressure, retrograde flow, and tissue blood flow (radioactive microspheres)--was studied in anesthetized dogs following acute occlusion of the left anterior descending coronary artery. AQ-A39 produced a significant (p less than 0.05) dose-related decrease in heart rate without any other hemodynamic changes. Retrograde flow and subendocardial blood flow were significantly increased by the lower dose of AQ-A39, whereas retrograde pressure, retrograde flow, and midmyocardial and subendocardial flow were increased by the higher dose. Atrial pacing to the control heart rate eliminated the beneficial effects of AQ-A39 on collateral function. These results suggest that an increase in collateral perfusion may be one mechanism by which AQ-A39 alleviates myocardial ischemia.
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Gross et al. (1987) studied Myocardial ischemia. AQ-A39 (Falipamil) was evaluated on Indices of collateral function (retrograde pressure, retrograde flow, and tissue blood flow) (p=<0.05). AQ-A39 decreased heart rate and increased retrograde and subendocardial blood flow in anesthetized dogs following acute coronary occlusion.
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