Why the study?
False lumen patency in acute type A aortic dissection is associated with adverse outcomes, but the role of coagulation defects in predicting false lumen fate is unclear.
Does a patent false lumen compared to a thrombosed false lumen reduce long-term survival in patients with acute type A aortic dissection?
Population
123 patients with acute type A aortic dissection
Comparison
Patent false lumen vs thrombosed false lumen
Design
Single-centre retrospective case-controlled study
Follow-up
Maximum 8.61 years
Key result
A patent false lumen in acute type A aortic dissection was associated with significantly reduced long-term survival compared to a thrombosed false lumen (HR 10.2; 95% CI 3.00-34.6; p<0.001).
Authors
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May support coagulation profiling for FL risk stratification in TAAD; leaves open confirmation in prospective cohorts.
Case-Control (n=123)
No
Does a patent false lumen compared to a thrombosed false lumen reduce long-term survival in patients with acute type A aortic dissection?
Hazard Ratio: 10.2 (95% CI 3–34.6)
p-value: p=<0.001
In patients with acute type A aortic dissection, a patent false lumen is associated with significantly reduced long-term survival and is predicted by intrinsic pathway coagulation abnormalities.
Thanalingam et al. (2026) conducted a case-control in Acute type A aortic dissection (TAAD) (n=123). Patent false lumen vs. Thrombosed false lumen was evaluated on long-term survival (HR 10.2, 95% CI 3.00-34.6, p=<0.001). A patent false lumen in acute type A aortic dissection was associated with significantly reduced long-term survival compared to a thrombosed false lumen (HR 10.2; 95% CI 3.00-34.6; p<0.001).
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