Key result
Review summarizes prorenin receptor binding properties and structural predictions to guide future 3D analysis.
Why the study?
Three-dimensional structural information of the (pro)renin receptor is lacking, limiting understanding of its binding properties and function.
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Design
Review summarizing binding properties and structure prediction of (pro)renin receptor
Answers are grounded in this paper and cite their sources.
Advances (pro)renin receptor binding insights; leaves open experimental 3D structures for therapeutic targeting.
The (pro)renin receptor is a single-spanning membrane protein that binds both renin and its inactive precursor prorenin. The receptor binding enhances the catalytic activity of renin and induces non-proteolytic activation of prorenin as well as triggers intracellular signaling with either renin or prorenin as a ligand. Threedimensional structural information of (pro)renin receptor is important to understand the receptor binding. This information is not available due to the lack of its threedimensional structure. In this review, we summarize the binding properties of (pro)renin receptor, provide the results of structure prediction and point out the issues to be tackled towards three-dimensional structural analysis of this receptor.
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Akio Ebihara (2012) reported a review. This review summarizes the binding properties of the (pro)renin receptor, provides structure prediction results, and highlights issues for future three-dimensional structural analysis.
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