Key result
Review outlines prorenin receptor binding properties and structural predictions to guide future 3D analysis.
Why the study?
Three-dimensional structural information of the (pro)renin receptor is lacking, which is important to understand its binding properties.
Highlights the need for three-dimensional structural analysis of the (pro)renin receptor to better understand its binding properties and signaling.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications; leaves open experimental validation of predicted (pro)renin receptor structures.
The (pro)renin receptor is a single-spanning membrane protein that binds both renin and its inactive precursor prorenin. The receptor binding enhances the catalytic activity of renin and induces non-proteolytic activation of prorenin as well as triggers intracellular signaling with either renin or prorenin as a ligand. Three-dimensional structural information of (pro)renin receptor is important to understand the receptor binding. This information is not available due to the lack of its three-dimensional structure. In this review, we summarize the binding properties of (pro)renin receptor, provide the results of structure prediction and point out the issues to be tackled towards three-dimensional structural analysis of this receptor.
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Akio Ebihara (2011) conducted a review in (pro)renin receptor binding. This review summarizes the binding properties of the (pro)renin receptor and provides structure prediction results to guide future three-dimensional structural analysis.
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