Key result
Catheter ablation for AF in elderly acute HF patients lacks reported quantitative outcome data.
Why the study?
The impact of catheter ablation for atrial fibrillation on clinical outcomes in elderly patients hospitalized for acute heart failure was unclear, especially in those aged 65 or older.
Does catheter ablation for atrial fibrillation reduce the composite of cardiac mortality and readmission for worsening HF in elderly patients hospitalized for acute heart failure?
Cohort (n=80)
Does catheter ablation for atrial fibrillation reduce the composite of cardiac mortality and readmission for worsening HF in elderly patients hospitalized for acute heart failure?
May support ablation consideration in selected elderly AF-HF patients; extends younger-trial data but leaves open need for dedicated RCTs.
Background: Very recently, the result of CASTLE-AF Clinical Trails has been announced. It showed that catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) was associated with better prognosis. However, mean age of the participant in this trial was 64 years old. And in the other similar studies, mean age was also in the 60's or less. Each AF and HF is increasing with age, and coexistence of both conditions also increases with age. Especially, for the elderly patients aged 80 or older, the loss of social resources related to HF admission is enormous in developed countries. Purpose: We investigated the impact of AF ablation on clinical outcome in elderly patients hospitalized for acute HF. Methods: Elderly patients aged 65 or older hospitalized for acute HF underwent AF ablation after the treatment of acute HF (Ablation group, n=17, range 65 to 89 years old). Control subjects were selected from consecutive patients aged 65 or older with AF who were hospitalized for acute HF before we started AF ablation (Non-ablation group, n=63). All patients were followed for 1 year. The endpoint was the composite endpoint of cardiac mortality and readmission for worsening HF.
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Manita et al. (2018) conducted a cohort in Atrial fibrillation and acute heart failure (n=80). Catheter ablation vs. No ablation was evaluated on Composite of cardiac mortality and readmission for worsening HF.
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