Key result
PAX5, MRPS22, and FTO minor allele homozygotes linked to ~8 kg greater fat mass and higher BP.
Why the study?
Hypertension is emerging in adolescence mainly due to obesity, and the genetic loci of obesity associated with elevated blood pressure in adolescence are not fully understood.
Are genome-wide identified gene loci of obesity associated with elevated blood pressure in adolescents?
Observational (n=598)
Are genome-wide identified gene loci of obesity associated with elevated blood pressure in adolescents?
p-value: p=9.3 × 10(-9)
Genome-wide association studies in adolescents identified novel obesity loci (PAX5, MRPS22) that are also associated with elevated blood pressure, highlighting the genetic architecture of obesity-induced hypertension.
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Obesity loci may flag adolescent hypertension risk; extends adult GWAS but leaves open causality and clinical utility.
Melka et al. (2011) conducted an observational in Adolescent obesity and elevated blood pressure (n=598). Obesity-associated genetic loci (PAX5, MRPS22, FTO) vs. Major allele homozygotes was evaluated on Total fat mass (TFM), body mass index (BMI), and blood pressure (BP) (p=9.3 × 10(-9)). Minor allele homozygotes of PAX5, MRPS22, and FTO loci were associated with greater total fat mass (by 2.9-8.0 kg) and higher blood pressure (by 3.3-6.7 mm Hg) than major allele homozygotes.
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