Key result
Perioperative beta-blocker withdrawal linked to ~261% higher 48-hour mortality risk after noncardiac surgery.
Why the study?
The relationship between perioperative beta-blocker withdrawal and mortality and cardiovascular-related critical quality indicators after noncardiac surgery has not been studied in a contemporary cohort.
Does withdrawal of perioperative beta-blockers increase mortality in patients on chronic beta-blocker therapy undergoing noncardiac surgery?
Cohort (n=19,145)
Does withdrawal of perioperative beta-blockers increase mortality in patients on chronic beta-blocker therapy undergoing noncardiac surgery?
Odds Ratio: 3.61 (95% CI 1.75–7.35)
p-value: p=0.0003
Perioperative withdrawal of beta-blockers in patients undergoing noncardiac surgery is associated with a more than 3-fold increased risk of mortality within 48 hours.
No takes yet. Share an insight, caveat, or question.
Caution against perioperative beta-blocker withdrawal in chronic users; leaves open causality and need for RCT confirmation.
Kertai et al. (2017) conducted a cohort in Noncardiac surgery on beta-blocker therapy (n=19,145). Perioperative withdrawal of beta-blockers vs. Continuation of beta-blockers was evaluated on Mortality within 48 hours postoperatively (OR 3.61, 95% CI 1.75-7.35, p=0.0003). Perioperative withdrawal of beta-blockers was associated with a significantly increased risk of mortality within 48 hours after noncardiac surgery (OR 3.61; 95% CI 1.75-7.35; P=0.0003).
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