Key result
Long-term preoperative β-blocker treatment was associated with elevated postoperative mortality and cardiac morbidity in patients with uncomplicated hypertension undergoing non-cardiac surgery.
Why the study?
Does long-term preoperative β-blocker treatment increase mortality and cardiac morbidity in patients with uncomplicated hypertension undergoing non-cardiac surgery?
Cohort
Yes
Does long-term preoperative β-blocker treatment increase mortality and cardiac morbidity in patients with uncomplicated hypertension undergoing non-cardiac surgery?
Preoperative beta-blocker treatment in patients with uncomplicated hypertension undergoing non-cardiac surgery is associated with increased postoperative mortality and cardiac morbidity.
Commentary on: Jørgensen ME, Hlatky MA, Køber L, et al. β-Blocker-associated risks in patients with uncomplicated hypertension undergoing noncardiac surgery. JAMA Intern Med 2015;175:1923–31.[OpenUrl][1][PubMed][2] The role of β-blockers in preventing cardiovascular complications of non-cardiac surgery is controversial. Early enthusiasm was dampened by accumulating trial data and concerns about the scientific validity of several trials. When studies with uncertain validity are excluded, meta-analyses of randomised trials show that perioperative β-blockers (started within 1 day before surgery) prevent postoperative myocardial infarction (MI), but increase the risks of stroke and death.1 This Danish nationwide cohort study evaluated the association of long-term preoperative β-blocker treatment with mortality and cardiac morbidity after non-cardiac surgery in patients with uncomplicated hypertension. Population-based healthcare databases were used to conduct … [1]: {openurl}?query=rft.jtitle%253DJAMA%2BIntern%2BMed%26rft.volume%253D175%26rft.spage%253D1923%26rft_id%253Dinfo%253Apmid%252F26436291%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=26436291&link_type=MED&atom=%2Febmed%2F21%2F3%2F114.atom
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Duminda N. Wijeysundera (2016) conducted a cohort in uncomplicated hypertension. long-term preoperative β-blocker treatment was evaluated on mortality and cardiac morbidity after non-cardiac surgery. Long-term preoperative β-blocker treatment was associated with elevated postoperative mortality and cardiac morbidity in patients with uncomplicated hypertension undergoing non-cardiac surgery.
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