Key result
Cold exposure increases C/EBP beta expression in adult rats, while fetal tissue expresses several-fold higher levels.
Why the study?
The specific regulation and role of C/EBP alpha and beta transcription factors in brown adipose tissue development and differentiation were not fully understood.
Population
Rat brown-adipose tissue from fetal and adult stages
Comparison
Cold environment exposure in adult rats versus normal environment and different developmental stages
Design
Preclinical study
Authors
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Animal data implicate C/EBP factors in rodent BAT development; leaves open human relevance or therapeutic targeting.
The C/EBP family of transcription factors appears to play an important role in the development and terminal differentiation of brown adipose tissue.
Manchado et al. (1994) studied Brown adipose tissue development. Cold environment exposure and developmental stage vs. Adult tissue or liver was evaluated on Expression of C/EBP alpha and beta mRNA and proteins. C/EBP alpha and beta expression is several-fold higher in fetal rat brown adipose tissue than in adult tissue, and cold exposure specifically increases C/EBP beta expression.
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