Key result
Exercise-based cardiac rehabilitation after TAVI significantly improves 6MWT performance.
Why the study?
While the beneficial effects of exercise training-based cardiac rehabilitation are established in other cardiac conditions, its potential impact in patients undergoing TAVI required evaluation.
Does exercise training-based cardiac rehabilitation improve exercise capacity and health-related quality of life in patients undergoing TAVI?
Meta-Analysis (n=685)
Does exercise training-based cardiac rehabilitation improve exercise capacity and health-related quality of life in patients undergoing TAVI?
Standardized Mean Difference: 0.59 (95% CI 0.48–0.71)
p-value: p=< 0.01
Exercise training-based cardiac rehabilitation following TAVI significantly improves physical capacity and health-related quality of life.
Supports post-TAVI CR to enhance exercise capacity and QoL; extends prior CR evidence to this growing population.
The beneficial effects of exercise training-based cardiac rehabilitation (CR) in different cardiac conditions have been previously studied. In this meta-analysis, we focused on the potential impact of CR on patients undergoing transcatheter aortic valve implantation (TAVI). Multiple databases were searched in a systematic approach to find the eligible studies. All the studies investigating the potential impact of exercise training-based CR programmes on exercise capacity and health-related quality of life in patients undergoing TAVI were retrieved. The primary endpoint of interest was 6-min walk test (6MWT). The pooled standardized mean difference (SMD) and 95 % confidence interval (CI) were measured to compare the improvement or worsening the endpoints using a random- or fixed-effects model, as appropriate. A total of eleven studies (685 patients) were considered eligible for quantitative synthesis. The results showed that performing exercise training-based CR after TAVI is associated with significant improvement in 6MWT (SMD 0.59, 95 % CI (0.48; 0.71), p < 0.01), Barthel index (SMD 0.73, 95 % CI (0.57; 0.89), p < 0.01), 12-item Short Form (SF-12) physical (SMD 0.30, 95 % CI (0.08; 0.52), p < 0.01) and mental (SMD 0.27, 95 % CI (0.05; 0.49), p = 0.02) survey scores, and hospital anxiety and depression scale – depression (HADS-D) score (SMD -0.26, 95 % CI (−0.42; −0.10), p < 0.01). Performing exercise training-based CR following TAVI has significant benefits regarding physical capacity and health-related quality of life irrespective of the programme duration.
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Hosseinpour et al. (2024) conducted a meta-analysis in Transcatheter aortic valve implantation (TAVI) (n=685). Exercise training-based cardiac rehabilitation was evaluated on 6-min walk test (6MWT) (SMD 0.59, 95% CI 0.48; 0.71, p=< 0.01). Exercise training-based cardiac rehabilitation after TAVI significantly improved 6-minute walk test performance (SMD 0.59; 95% CI 0.48-0.71; p<0.01).
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