Key result
Tumor necrosis and perineural invasion are linked to decreased survival in resected Stage B colorectal cancer.
Why the study?
Clinical and pathologic variables associated with poor outcome after resection of Stage B colorectal cancer were not well defined.
What clinical and pathologic variables are associated with poor outcome following resection of Stage B colorectal cancer?
Observational (n=117)
Single-blind
What clinical and pathologic variables are associated with poor outcome following resection of Stage B colorectal cancer?
p-value: p=0.01 (necrosis), 0.03 (perineural invasion)
Tumor necrosis and perineural invasion are independent prognostic indicators for poor outcome in Stage B colorectal cancer patients following curative surgery.
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Tumor necrosis and perineural invasion may stratify prognosis after Stage B colorectal cancer resection; hypothesis-generating for tailored adjuvant strategies.
Mulcahy et al. (1997) conducted an observational in Stage B colorectal cancer (n=117). Clinical and pathologic variables (e.g., tumor necrosis, perineural invasion) vs. Absence of these variables was evaluated on Poor outcome (tumor recurrence and death) (p=0.01 (necrosis), 0.03 (perineural invasion)). Tumor necrosis (P=0.01) and perineural invasion (P=0.03) were independently associated with poor outcomes and decreased survival in patients with resected Stage B colorectal cancer.
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