What does this research mean for the field?

Although national hepatocellular carcinoma incidence rates in the United States have declined in recent years, these trends vary significantly across different geographic census divisions and racial/ethnic groups. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To update secular trends in United States hepatocellular carcinoma incidence from 2001 to 2021 and evaluate regional and racial/ethnic disparities across all nine census divisions.

April 24, 2025CancersOpen Access

Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021

View Full Paper

Ask AI

Bookmark

Authors

ISItunu O. SokaleBaylor College of Medicine OROmar RosalesBaylor University ATAaron P. ThriftBaylor College of Medicine

Discussion

Member takes

Implication

Registry analysis reveals diverging hepatocellular carcinoma incidence trends across demographic groups in the United States, highlighting the need for tailored regional interventions.

Key Points

To update secular trends in United States hepatocellular carcinoma incidence from 2001 to 2021 and evaluate regional and racial/ethnic disparities across all nine census divisions.
Analyzed hepatocellular carcinoma incidence data from the United States Cancer Statistics database covering 2001 to 2021, excluding 2020 due to COVID-19-related reporting distortions.
Calculated age-adjusted incidence rates nationwide, across nine census divisions, and stratified by racial and ethnic groups using the Joinpoint Regression Program.
National hepatocellular carcinoma incidence increased from 2001 to 2021 with an AAPC of 2.51 (95% CI: 2.32–2.72), before decreasing between 2018 and 2021 with an APC of −3.33 (95% CI: −4.78 to −1.96).
Division 1 experienced the steepest recent drop with an APC of −6.46 (95% CI: −9.62 to −3.96) from 2017 to 2021, whereas incidence rates plateaued in Division 6 and Division 7.
Recent incidence rates declined markedly among non-Hispanic Black and non-Hispanic Asian/Pacific Islander populations across nearly all divisions, while remaining stable, increasing, or decreasing in other racial and ethnic groups.

Cite This Study

Sokale et al. (2025) studied this question.

synapsesocial.com/papers/6aaa08dcbf5b892176fc9cff https://doi.org/10.3390/cancers17091431

View Full Paper

Ask AI

Bookmark

Implication

Registry analysis reveals diverging hepatocellular carcinoma incidence trends across demographic groups in the United States, highlighting the need for tailored regional interventions.

Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021

Discussion

Member takes

Implication

Key Points

Cite This Study

Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider