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November 1, 1981Journal of Applied Physiology

Breuer-Hering inflation reflex and breathing pattern in anesthetized humans and cats

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Key result

End-inspiratory occlusion provokes apnea in humans and cats, but hypercapnia decreases inspiratory duration only in cats.

  • n=18

Why the study?

The role of the Breuer-Hering inflation reflex in controlling inspiratory off-switch during increased respiratory activity from hypercapnia in humans and cats was unclear.

Comparison

Airway occlusion at end inspiration or expiration, lung inflations at end expiration, and hypercapnia versus baseline respiratory activity

Design

Physiological study measuring respiratory activity and tracheal pressure

Authors

HGH. GautierDartmouth CollegeMBM. BonoraDartmouth CollegeJGJ.H. GAUDY

Discussion

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Implication

Species differences in Breuer-Hering reflex response during hypercapnia warrant caution extrapolating animal data; leaves open its role in human respiratory control.

Structured PICO

P
Population
9 cats and 9 human subjects anesthetized with alfaxalone undergoing airway occlusion and hypercapnia.
I
Intervention
Airway occlusion at end inspiration or end expiration, lung inflations at end expiration, and hypercapnia
C
Comparator
Baseline respiratory activity prior to occlusion or inflation
O
Outcome
Respiratory activity and tracheal pressure (including apnea provocation and inspiratory duration)surrogate

The Breuer-Hering inflation reflex is operative in humans but does not appear to control the inspiratory off-switch mechanism during hypercapnia-induced increases in respiratory activity.

Cite This Study

Gautier et al. (1981) studied Anesthetized with alfaxalone (n=18). Airway occlusion and hypercapnia vs. Baseline was evaluated on Respiratory activity and inspiratory duration. Airway occlusion at end-inspiration provoked apnea in both cats and humans, but during hypercapnia, inspiratory duration decreased in cats and did not change in humans.

synapsesocial.com/papers/6aaa0a3d3e26af5d367e5ccdhttps://doi.org/10.1152/jappl.1981.51.5.1162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On the regulation of depth and rate of breathing1972 · 717 citations
  2. 2RE‐EVALUATION OF RESPIRATORY REFLEXES1966 · 49 citations
  3. 3Some reflex cardioinhibitory responses in the cat and their modulation by central inspiratory neuronal activity.1991 · 44 citations
  4. 4Differential modulation by pulmonary stretch afferents of some reflex cardioinhibitory responses in the cat.1989 · 43 citations
  5. 5Use‐dependent learning and memory of the Hering–Breuer inflation reflex in rats2008 · 13 citations