Key result
An 8-minute unilateral lung inflation or vagal stimulation in rats resulted in significantly longer short-term memory time constants for respiratory durations compared to a 1-minute test (P<0.01).
Population
Anaesthetized, uni- or bi-vagotomized rats
Comparison
1 or 8 min unilateral lung inflation or… vs 1 min vs 8 min test duration
Design
Preclinical
Authors
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Hypothesis-generating for use-dependent memory in Hering-Breuer reflex desensitization; human studies needed before clinical relevance.
p-value: p=< 0.01
The short-term memory of desensitization in the Hering-Breuer inflation reflex is use-dependent in rats.
MacDonald et al. (2008) studied Anaesthetized, uni- or bi-vagotomized rats. 8 min unilateral lung inflation or vagal stimulation vs. 1 min unilateral lung inflation or vagal stimulation was evaluated on Short-term memory (STM) time constants for inspiratory and expiratory durations (t(I) and t(E)) (p=< 0.01). An 8-minute unilateral lung inflation or vagal stimulation in rats resulted in significantly longer short-term memory time constants for respiratory durations compared to a 1-minute test (P<0.01).
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