Key result
The normalized size of the initial inhibitory response to inspiratory loading did not differ significantly between spontaneous hypercapnic hyperpnea (65%) and voluntary hyperventilation (67%, P=0.50).
Population
11 subjects
Comparison
Transient loading of inspiration during… vs Transient loading of inspiration during matched…
Design
Other
Authors
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Reflex unaffected by hypercapnia; leaves open spinal or non-medullary mediation and requires targeted circuit studies.
Absolute Event Rate: 65% vs 67%
p-value: p=0.50
The lack of difference in the size of the initial inhibitory response between spontaneous and voluntary hyperventilation suggests that the reflex arc does not transit brain stem inspiratory centers and may be integrated at the spinal level.
Murray et al. (2010) studied this question. Spontaneous hypercapnic hyperpnea vs. Matched voluntary hyperventilation was evaluated on Normalized size of the initial inhibitory response (IR) (p=0.50). The normalized size of the initial inhibitory response to inspiratory loading did not differ significantly between spontaneous hypercapnic hyperpnea (65%) and voluntary hyperventilation (67%, P=0.50).
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