Key result
Multiparametric cardiac MRI demonstrates high diagnostic accuracy for pulmonary hypertension with ~93% sensitivity.
Why the study?
Accurate noninvasive diagnosis of pulmonary hypertension using cardiac MRI requires validated multiparametric models compared to right-sided heart catheterization.
Do multiparametric cardiac MRI models accurately diagnose pulmonary hypertension compared to right-sided heart catheterization in patients suspected of having PH?
Cohort (n=603)
Do multiparametric cardiac MRI models accurately diagnose pulmonary hypertension compared to right-sided heart catheterization in patients suspected of having PH?
Effect estimate: AUC 0.95 (95% CI 0.93, 0.98)
Multiparametric cardiac MRI models demonstrate high diagnostic accuracy for pulmonary hypertension when compared to the reference standard of right heart catheterization.
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Supports noninvasive PH evaluation in suspected cases; leaves open replacement of catheterization pending prospective validation.
Johns et al. (2018) conducted a cohort in Pulmonary hypertension (n=603). Multiparametric cardiac MRI models vs. Right-sided heart catheterization was evaluated on Diagnostic accuracy (area under the ROC curve) of cardiac MRI mPAP model 1 (AUC 0.95, 95% CI 0.93, 0.98). A multiparametric cardiac MRI model demonstrated high diagnostic accuracy for pulmonary hypertension (AUC 0.95; 95% CI 0.93-0.98), with 93% sensitivity and 79% specificity at a ≥25 mm Hg threshold.
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