Key result
68Ga-PSMA PET/CT incidentally detects radiation-induced sarcoma in a post-radiotherapy prostate cancer patient.
Case Report (n=1)
68Ga-PSMA PET/CT can incidentally detect radiation-induced sarcomas due to binding to tumor neovasculature, warranting careful review of previously irradiated areas.
Incidental PSMA uptake in irradiated fields may signal sarcoma; leaves open systematic evaluation in prospective cohorts.
Radiation-induced sarcoma is a rare complication of radiation therapy. We describe the incidental detection of a radiation-induced undifferentiated soft-tissue sarcoma with increased uptake on Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT in a prostate cancer patient previously treated with surgery and external-beam radiotherapy. Results were confirmed by histological analysis. Ga-PSMA is known to bind not only to PSMA-expressing prostate cancer cells but also to the neovasculature of various other solid tumors. A careful Ga-PSMA PET/CT review of previously irradiated areas is warranted so as not to miss radiation-induced sarcoma in prostate cancer patients.
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Plouznikoff et al. (2019) conducted a case report in Prostate cancer and radiation-induced sarcoma (n=1). 68Ga-PSMA PET/CT was evaluated on Incidental detection of radiation-induced sarcoma. 68Ga-PSMA PET/CT incidentally detected a radiation-induced undifferentiated soft-tissue sarcoma with increased uptake in a prostate cancer patient previously treated with radiotherapy.
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