What does this research mean for the field?

Simulated normal blood flow waveforms stimulate significantly greater prostacyclin production in canine femoral arteries than abnormal waveforms at the same mean flow rate. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1991Circulation ResearchOpen Access

Simulated blood flow and the effects on prostacyclin production in the dog femoral artery.

Q: What are the key findings of this study?

Simulated normal blood flow in canine femoral arteries resulted in a significantly higher acute response of prostacyclin production compared to abnormal flow (5.87 vs 2.20 ng/cm2/5 min, p<0.01).

Q: What is the clinical evidence from this study?

Study design: Other. Population: Canine femoral artery perfused ex vivo (n=14). Intervention: Simulated normal blood flow waveform vs. Simulated abnormal blood flow waveform. Primary outcome: Acute response of PGI2 production (cumulative production for the first 5 minutes) (p=<0.01).

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Key result

Simulated normal blood flow yields ~167% higher acute PGI2 production versus abnormal flow in canine arteries.

P<0.01
n=14

Why the study?

The effects of different blood flow waveforms on prostacyclin production in the canine femoral artery were not well understood.

Does a simulated normal blood flow waveform improve prostacyclin production in canine femoral arteries compared to an abnormal flow waveform?

Comparison

Simulated normal flow waveform vs simulated abnormal flow waveform

Design

Ex vivo experimental study with simulated flow apparatus

Follow-up

30 minutes

Authors

TOToshihiro OnoharaNational Kyushu Medical Center KOKenichiro OkadomeKyushu University SYShinji YamamuraKumamoto University

Discussion

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Implication

Does not support clinical changes in graft flow design; leaves open flow-prostacyclin mechanisms in human graft failure.

Structured PICO

Does a simulated normal blood flow waveform improve prostacyclin production in canine femoral arteries compared to an abnormal flow waveform?

Population

14 canine femoral arteries perfused ex vivo to examine the effects of simulated normal versus abnormal blood flow waveforms on prostacyclin production.

Intervention

Simulated normal blood flow waveform (steep acceleration followed by steep deceleration)

Comparator

Simulated abnormal blood flow waveform (gentle sloping waveform in the deceleration phase)

Outcome

Prostacyclin (PGI2) production measured as 6-ketoprostaglandin F1 alpha (acute response for the first 5 minutes and stable production rate after the first 30 minutes)surrogate

Main Result

Absolute Event Rate: 5.87% vs 2.2%

p-value: p=<0.01

Simulated normal blood flow waveforms significantly increase prostacyclin production in canine femoral arteries compared to abnormal flow waveforms, suggesting a mechanism for late graft failure.

Cite This Study

Onohara et al. (1991) studied Canine femoral artery perfused ex vivo (n=14). Simulated normal blood flow waveform vs. Simulated abnormal blood flow waveform was evaluated on Acute response of PGI2 production (cumulative production for the first 5 minutes) (p=<0.01). Simulated normal blood flow in canine femoral arteries resulted in a significantly higher acute response of prostacyclin production compared to abnormal flow (5.87 vs 2.20 ng/cm2/5 min, p<0.01).

synapsesocial.com/papers/6aaa0e4c207060c46bfbbf90 https://doi.org/10.1161/01.res.68.4.1095

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Simulated blood flow and the effects on prostacyclin production in the dog femoral artery.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Simulated blood flow and the effects on prostacyclin production in the dog femoral artery.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider