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July 23, 2026ResuscitationOpen Access

One-year liver graft survival from brain-dead donors treated with ECPR for out-of-hospital cardiac arrest

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Authors

JRJean‐Herlé RaphalenTSTal SoumagnacRMRaphaël Merle-Beral

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Overview

Observational study finds an 80% one-year liver graft survival rate in brain-dead donors treated with ECPR versus 89% in controls, suggesting potential utility in expanding donor pools.

Key Points

  • To evaluate one-year liver graft survival among brain-dead organ donors treated with extracorporeal cardiopulmonary resuscitation (ECPR) for refractory out-of-hospital cardiac arrest.
  • Single-centre retrospective observational study conducted between January 2011 and June 2024.
  • Evaluated brain-dead donors who donated at least one organ, comparing an ECPR group (treated for refractory out-of-hospital cardiac arrest) against a control group not treated with ECPR.
  • Assessed primary outcome of one-year liver graft survival alongside organ retrieval rates and donor clinical characteristics.
  • Liver retrieval was performed in 15/38 (39%) potential donors in the ECPR group compared with 27/34 (79%) potential donors in the control group (P < 0.01).
  • Actual ECPR donors were younger (median age 47 vs. 70 years, P < 0.01) with higher peak lactate levels (median 9.4 vs. 3.0 mmol/L, P < 0.01).
  • One-year liver graft survival did not differ significantly between arms, occurring in 12/15 (80%; 95% CI, 55-93) in the ECPR group versus 24/27 (89%; 95% CI, 72-96) in the control group (P = 0.65).

Cite This Study

Raphalen et al. (2026) studied this question.

synapsesocial.com/papers/6aaa0ecd2f1eb85158fc9f67https://doi.org/10.1016/j.resuscitation.2026.111219
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