Synthesis of Some Novel 2-Aminothiophene Derivatives and Evaluation for Their Antimicrobial Activity

Chemistry of 2-aminothiophenes is arguably one of the most extensive and dynamic field of present-day research.Highly substituted thiophene derivatives are important heterocyclic compounds found in numerous biologically active and natural compounds.2-aminothiophenesforms a significant class of drugs which exhibits the excellent biological activities like antimicrobial, antifungal, anti-inflammatory, analgesic, antioxidant, antitumor activities.In continuation of our previous studies on synthesis of substituted 2-aminothiophenes and due to their significant biological properties, we now report the newly synthesized ethyl 2-amino-4-phenylthiophene-3-carboxylate derivatives are obtained by base protanated reaction between ketone, elemental sulphur with ethylcayanoacetate in the presence of diethyl amine.The newely synthesized targeted compounds were characterized by spectral analysis studies and screened for their antibacterial activity by using minimum inhibitory concentration (MIC) method by taking ampicilline and streptomycine as standard.