Key result
Increasing pacemaker basal rate abolishes VF in a pediatric case of bradycardia-induced acquired LQTS.
Why the study?
The mechanisms and clinical implications of bradycardia-induced acquired long-QT syndrome leading to ventricular fibrillation in pediatric patients with pacemakers are not well characterized.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
In pediatric patients, an inappropriately low basal pacing rate can lead to bradycardia-induced acquired long-QT syndrome and life-threatening ventricular fibrillation.
After undergoing surgery for a perimembranous ventricular septal defect and discrete membrane resection, a 7-year-old patient developed complete atrioventricular block and received an epicardial pacemaker.When the epicardial pacemaker reached end-of-life status, a transvenous pacemaker was implanted.Due to the low basal rate setting of this newly implanted transvenous pacemaker, the patient experienced bradycardia-induced acquired long-QT syndrome (LQTS), subsequently resulting in episodes of ventricular fibrillation.This case report discusses the mechanisms leading to acquired LQTS and fibrillation, and emphasizes the importance of an appropriate basal pacing rate, especially in pediatric patients, to avoid life-threatening arrhythmias.
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Yıldız et al. (2025) conducted a case report in Acquired long-QT syndrome and ventricular fibrillation (n=1). Pacemaker basal rate adjustment vs. 50 bpm was evaluated on Ventricular fibrillation episodes. Increasing the pacemaker basal rate from 50 bpm to 90 bpm abolished ventricular fibrillation episodes caused by bradycardia-induced acquired long-QT syndrome in a pediatric patient.
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