P418: A genome sequencing approach to pharmacogenomic profiling across diverse population in a large health system

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Genome sequencing can be utilized as an alternative to traditional gene panels for pharmacogenomic profiling in large, diverse health systems. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yuan Li; Isabelle Lucas Beckett

doi:10.1016/j.gimo.2023.100454

January 1, 2023Genetics in Medicine OpenOpen Access

P418: A genome sequencing approach to pharmacogenomic profiling across diverse population in a large health system

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Abstract

Due to the variability in drug efficacy and safety attributed to an individual’s genetic profile, pharmacogenomics (PGx) is rapidly becoming a cornerstone of precision medicine. PGx testing has traditionally been conducted through selected gene panels with pre-defined variants. Through the Genomic Medicine for Everyone (Geno4ME) program, we piloted PGx using a genome sequencing method in the highly diverse seven-state Providence Health System.

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Li et al. (2023) studied this question.

synapsesocial.com/papers/6aaa19e6f92ab359461c0193 https://doi.org/10.1016/j.gimo.2023.100454

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P418: A genome sequencing approach to pharmacogenomic profiling across diverse population in a large health system

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P418: A genome sequencing approach to pharmacogenomic profiling across diverse population in a large health system

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