Key result
Loop recorder monitoring offers an alternative to ICD implantation in atypical Brugada syndrome syncope.
Why the study?
Clinical implications of a variant in SCN5A in Brugada syndrome with syncope suggestive of vasovagal origin require clarification for management decisions.
In a patient with Brugada syndrome and an SCN5A variant, syncope of suspected vasovagal origin did not warrant ICD implantation, highlighting the importance of careful clinical phenotyping in genetic channelopathies.
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Ortiz et al. (2026) studied this question. A Brugada syndrome patient with an SCN5A variant and vasovagal-suggestive syncope did not meet ICD implantation criteria, resulting in a recommendation for loop recorder monitoring.
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