Key result
Population-based AAA screening cuts AAA-related mortality ~45% in men 65 and older versus control.
Why the study?
It remains unclear whether population-based screening for abdominal aortic aneurysm in men reduces all-cause long-term mortality.
Does population-based screening for AAA reduce long-term mortality in men aged ≥ 65 years?
Population
Men aged ≥ 65 years from four randomized controlled trials
Comparison
Population-based AAA screening vs control (no screening)
Design
Meta-analysis of randomized controlled trials
Follow-up
≥ 10 years
Authors
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Supports AAA screening consideration in men ≥65; leaves open need for randomized confirmation in contemporary cohorts.
Meta-Analysis
Does population-based screening for AAA reduce long-term mortality in men aged ≥ 65 years?
Odds Ratio: 0.55 (95% CI 0.36–0.86)
Absolute Risk Reduction: 0.4%
Number Needed to Treat: 238
p-value: p=.008
Population-based screening for AAA in men aged ≥ 65 years significantly reduces AAA-related long-term mortality but does not reach statistical significance for reducing all-cause mortality.
Takagi et al. (2010) conducted a meta-analysis in abdominal aortic aneurysm. Population-based screening for abdominal aortic aneurysm vs. control was evaluated on AAA-related mortality (OR 0.55, 95% CI 0.36 to 0.86, p=.008). Population-based screening for abdominal aortic aneurysm in men aged ≥ 65 years significantly reduced AAA-related mortality (OR 0.55; 95% CI 0.36-0.86; P=0.008) compared to control.
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