Key result
Periodic shear alterations increase albumin uptake via an adaptive permeability response taking ~1 hour.
Why the study?
Changes in arterial wall fluid dynamics with time constants of minutes to hours may prompt adaptive responses that transiently increase endothelial permeability, but this has not been experimentally tested.
Changes in the fluid dynamic environment of the arterial wall prompt adaptive responses that transiently increase endothelial permeability.
Does not alter clinical vascular management; leaves open adaptive permeability as a mechanistic target in human arteries.
Experiments were carried out in swine to test the hypothesis that changes in the fluid dynamic environment of the arterial wall, with time constants of several minutes to perhaps a few hours, prompt adaptive responses that transiently increase endothelial permeability. After parenteral Evans Blue Dye (EBD) administration, the hemodynamics of the external iliac arteries of the experimental animals were altered using a reversible arteriovenous femoral shunt. For 3 h, the shunt was opened and closed with a period (tau) between 1-180 min. Subsequently, the animal was euthanized and the iliac vessels were photographed en face to obtain the distribution of EBD-bound albumin uptake by the tissue during its exposure to the dye. Albumin uptake increases with tau in a fashion that can be explained by an a priori model of the adaptive permeability response, with a time constant of about an hour.
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Friedman et al. (2000) studied this question. Periodic alterations in shear using a reversible arteriovenous femoral shunt was evaluated on Distribution of EBD-bound albumin uptake by the tissue. Periodic alterations in shear increased albumin uptake with the period (tau) in a manner consistent with an adaptive permeability response having a time constant of about an hour.
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