January 1, 1983Clinical Pharmacology & Therapeutics
How a cigarette is smoked determines blood nicotine levels
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Discussion
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Implication
Experimental study finds individual smoking behavior drives blood nicotine uptake in smokers, indicating that machine cigarette yields do not accurately reflect real chemical exposure.
Key Points
- Determine whether individual smoking behaviors affect post-smoking blood nicotine and carbon monoxide levels compared to machine-measured cigarette yields.
- Assessed 11 subjects while smoking two or four tobacco cigarettes of varying machine-determined yields.
- Measured puff volume, puff duration, puff count, interpuff interval, and inhalation volume and duration.
- Quantified nicotine blood levels and breath carbon monoxide before and after smoking.
- Machine-determined nicotine yield alone showed a moderate correlation with post-smoking increases in blood nicotine levels (r = 0.52).
- Accounting for individual differences in smoking behavior alongside cigarette yield substantially increased the correlation with blood nicotine levels (r = 0.84 to 0.93).
Cite This Study
Herning et al. (1983) studied this question.