July 1, 1984Clinical Pharmacology & Therapeutics
Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking
Key result
Smoking high- or low-nicotine cigarettes did not differentially affect 24-hour heart rate compared to usual brands, indicating nicotine amount has little influence on cardiovascular responses.
Why the study?
Does the nicotine content of cigarettes influence cardiovascular and hormonal responses in healthy subjects?
Population
10 healthy subjects
Comparison
Smoking high-nicotine or low-nicotine research… vs Abstaining from smoking
Design
Other
Follow-up
24 hours
Authors
Discussion
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Implication
Nicotine reduction may not mitigate smoking-related heart rate changes; leaves open contributions from other tobacco constituents.
Structured PICO
Does the nicotine content of cigarettes influence cardiovascular and hormonal responses in healthy subjects?
P
Population
10 healthy subjects studied on a research ward while smoking usual brand, high-nicotine, low-nicotine cigarettes, or abstaining.
I
Intervention
Smoking high-nicotine (2.5 mg) or low-nicotine (0.4 mg) research cigarettes, or usual brand
C
Comparator
Abstaining from smoking
O
Outcome
Mean (24-hr) heart ratesurrogate
The amount of nicotine consumed has little influence on the magnitude of cardiovascular responses to cigarette smoking, suggesting that reducing nicotine content alone may not alter the associated cardiovascular risk.
Cite This Study
Benowitz et al. (1984) studied Healthy subjects (n=10). High- and low-nicotine research cigarettes vs. Usual brand of cigarettes or abstaining was evaluated on Mean (24-hr) heart rate. Smoking high- or low-nicotine cigarettes did not differentially affect 24-hour heart rate compared to usual brands, indicating nicotine amount has little influence on cardiovascular responses.