Key result
Oral nicotine reduces heart rate variability and shifts autonomic balance toward sympathetic predominance.
Why the study?
The authors sought to explore whether nicotine, the main component of tobacco, has adverse effects on heart rate variability in adolescents.
Does acute nicotine ingestion reduce heart rate variability in young healthy nonsmoking adults?
RCT (n=80)
Double-blind
Randomly assigned order (crossover design)
No
Does acute nicotine ingestion reduce heart rate variability in young healthy nonsmoking adults?
Answers are grounded in this paper and cite their sources.
Acute nicotine ingestion reduces heart rate variability and increases sympathetic activity in young healthy adults, suggesting that nicotine replacement therapy carries cardiovascular autonomic risks independent of smoking.
Around the whole world, smoking is considered harmful to human health, such as increasing the risk of cardiovascular disease (CVD, such as coronary heart disease and stroke) and lung cancer. The purpose of this study was to explore whether nicotine, the main component of tobacco, has adverse effects on heart rate variability (HRV) in adolescents, so as to remind adolescents not to smoke and not to take pleasure in abusing nicotine. In this study, 40 male and 40 female young healthy nonsmoking subjects were selected to analyze the changes of HRV after taking 4 mg nicotine orally. We found that nicotine reduced HRV in young healthy male and female subjects, and there was no gender difference in this effect ( P > 0.05). In conclusion, smoking is harmful to the cardiac system of young people, especially when nicotine content ≥4 mg dosage.
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Guo et al. (2022) conducted an RCT in Healthy nonsmokers (n=80). Nicotine (Nicabate CQ lozenge) vs. Mint lozenge (placebo) was evaluated on Heart rate variability (LF, HF, LF/HF, HR) at 20 minutes post-ingestion (p=<0.05). Oral ingestion of 4 mg nicotine significantly reduced heart rate variability and shifted cardiac autonomic modulation to a sympathetic predominant state compared to baseline (p<0.05).
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