Key result
A single 4 mg oral nicotine lozenge significantly reduced heart rate variability, increasing the LF/HF ratio from 2.9 to 3.7 (p < .01) in healthy young nonsmokers.
Why the study?
Does a single 4 mg oral nicotine lozenge decrease heart rate variability in healthy nicotine-naive subjects?
Population
40 healthy nicotine-naive subjects (20 males, 20 females) aged between 18 and 25 years
Comparison
4 mg oral nicotine lozenge vs Placebo
Design
Other
Follow-up
15-30 min postingestion
Authors
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Acute nicotine may suppress vagal tone in nonsmokers; leaves open NRT autonomic effects in nicotine-naive patients.
RCT (n=40)
Does a single 4 mg oral nicotine lozenge decrease heart rate variability in healthy nicotine-naive subjects?
p-value: p=<.01
A single 4 mg oral nicotine dose significantly reduces heart rate variability in healthy young nonsmokers, indicating reduced vagal activity.
Sjoberg et al. (2011) conducted an RCT in Healthy nonsmokers (n=40). Oral nicotine lozenge vs. Placebo was evaluated on Heart rate variability (HRV) (p=<.01). A single 4 mg oral nicotine lozenge significantly reduced heart rate variability, increasing the LF/HF ratio from 2.9 to 3.7 (p < .01) in healthy young nonsmokers.
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