Why the study?
Does nicotine gum alter cardiac hemodynamics and conduction in healthy nonsmoking adults?
Population
11 healthy nonsmoking adults (6 male, 5 female; ages 23-36 years)
Comparison
Nicotine gum (4 mg) chewed for 20 minutes vs Placebo gum
Design
RCT, randomized, cross-over, double-blind
Follow-up
40 minutes
Authors
Loading...
Nicotine gum warrants caution in patients with CV risk due to acute hemodynamic strain; extends RCT evidence on afterload and conduction effects to nonsmokers.
Does nicotine gum alter cardiac hemodynamics and conduction in healthy nonsmoking adults?
Nicotine chewing gum acutely increases afterload, cardiac output, heart rate, and P wave duration without changing cardiac contractility in healthy nonsmokers.
Jolma et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: