March 1, 2000Journal of Cardiovascular Pharmacology
Short-Term Effects of Smoking and Nicotine Chewing Gum on Endothelium-Dependent Vasodilation in Young Healthy Habitual Smokers
Why the study?
Does smoking or nicotine gum acutely impair endothelium-dependent vasodilation in young healthy habitual smokers?
Population
Young healthy habitual smokers (n=10 for smoking assessment, n=6 for nicotine gum assessment)
Comparison
Smoking a cigarette or chewing nicotine gum (4 mg) vs Baseline measurements
Design
Other
Follow-up
30-50 minutes
Authors
Discussion
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Member takes
Implication
Acute nicotine exposure may impair endothelial function; supports mechanistic research but should not yet change practice.
Structured PICO
Does smoking or nicotine gum acutely impair endothelium-dependent vasodilation in young healthy habitual smokers?
P
Population
Young healthy habitual smokers (n=10 for smoking assessment, n=6 for nicotine gum assessment)
I
Intervention
Smoking a cigarette or chewing nicotine gum (4 mg)
C
Comparator
Baseline measurements (before smoking or chewing gum)
O
Outcome
Endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIDV) assessed by forearm vascular resistance (FVR) during local infusion of metacholine and sodium nitroprussidesurrogate
Both cigarette smoking and nicotine chewing gum induce acute, dose-dependent impairment of endothelium-dependent vasodilation in healthy smokers.
Cite This Study
Sarabi et al. (2000) studied this question.