Why the study?
Does 4 mg nicotine chewing gum alter coronary blood flow and oxygen transport in healthy non-smoking men?
Population
8 healthy non-smoking men
Comparison
4 mg nicotine administered in a chewing gum vs Baseline and atrial pacing without nicotine
Design
Other
Authors
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Nicotine may increase myocardial O2 demand beyond rate-pressure product in healthy men; leaves open net coronary effects in smokers or CAD.
Does 4 mg nicotine chewing gum alter coronary blood flow and oxygen transport in healthy non-smoking men?
Nicotine exerts both indirect vasodilatory and direct vasoconstrictory effects on the coronary circulation in healthy humans.
Kaijser et al. (1985) studied this question.
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