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February 6, 2014Scandinavian Journal of Rheumatology

Increased percentages of PD-1 on CD4+T cells is associated with higher INF-γ production and altered IL-17 production in patients with systemic lupus erythematosus

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Authors

SDSebastian DolffDQDaniel QuandtTFThorsten Feldkamp

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Overview

Case-control study reveals elevated PD-1 on CD4+ T cells linked to altered IFN-γ and IL-17 in systemic lupus erythematosus, suggesting distinct immune dysregulation across disease subsets.

Key Points

  • To evaluate the expression of the PD-1 receptor on effector T cells and its association with IFN-γ and IL-17 production in patients with systemic lupus erythematosus.
  • Enrolled 32 patients with systemic lupus erythematosus (SLE) and 31 healthy controls.
  • Analyzed peripheral blood T cells using flow cytometry to quantify PD-1 expression alongside intracellular IFN-γ and IL-17 levels.
  • Percentages of CD4+ T cells expressing PD-1 were significantly increased in SLE patients compared to healthy controls and strongly correlated with IFN-γ production (r = 0.83, p < 0.0001).
  • IL-17 production by PD-1+ CD3+ T cells was significantly decreased in inactive SLE patients (3.2 ± 1.2% vs. 5.9 ± 3.5%, p = 0.002) and patients without lupus nephritis (3.2 ± 1.5% vs. 5.9 ± 3.5%, p = 0.005) relative to healthy controls.

Cite This Study

Dolff et al. (2014) studied this question.

synapsesocial.com/papers/6aaa22b7f830d21e1935ed76https://doi.org/10.3109/03009742.2013.869830
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PD-1 expressing B cells are expanded in lupus 44522025
  2. 2Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus2024 · 2 citations
  3. 3Association of Serum Programmed Cell Death Protein 1 (PD-1) and Gene Polymorphism with Some Valid Predictors for Systemic Lupus Erythematosus (SLE) Patients in Basra Province, Iraq2024
  4. 4PD-1 deficiency reshapes the TCRβ repertoire and T-cell developmental programs associated with susceptibility to lupus-like autoimmunity2026
  5. 5Insufficient PD-1 expression during active autoimmune responses: a deep single-cell proteomics analysis in inflammatory arthritis2024 · 8 citations