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November 1, 2025The Journal of ImmunologyOpen Access

PD-1 expressing B cells are expanded in lupus 4452

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Authors

MPMelanie PerkinsNMNida MeednuDKDaria Krenitsky

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Overview

Analysis shows increased PD-1 expression in B cells of lupus patients, suggesting connections to disease severity and autoimmunity.

Key Points

  • This research aims to understand the role of PD-1 expressing B cells in lupus and their potential pathogenicity.
  • Examined PD-1 expression on peripheral blood B cells using flow and mass cytometry.
  • Compared B cells from lupus patients and healthy controls across two large cohorts.
  • Characterized subsets of PD-1+ B cells and their relation to disease activity.
  • PD-1 was increased on antigen experienced B cells in lupus patients.
  • Identified a pathogenic PD-1+CD11c+CXCR3+ B cell subset potentially linked to inflammation.
  • Higher PD-1 expression correlated with increased anti-dsDNA levels and disease activity.

Cite This Study

Perkins et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3597f9https://doi.org/10.1093/jimmun/vkaf283.2134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PD-1 deficiency reshapes the TCRβ repertoire and T-cell developmental programs associated with susceptibility to lupus-like autoimmunity2026
  2. 2Increased percentages of PD-1 on CD4+T cells is associated with higher INF-γ production and altered IL-17 production in patients with systemic lupus erythematosus2014 · 35 citations
  3. 3Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus2024 · 2 citations
  4. 4Bridging B-cell autoimmunity and oncology: the PD-1/PD-L1 paradox in systemic lupus erythematosus2026
  5. 5PD-1 regulates CD4 T cell differentiation and trafficking in response to hyperlipidemia in mice and humans 22609722026