Key result
Elevated circulating miR-133a, unlike fibrosis markers, is linked to RV impairment in DCM.
Why the study?
The relationship between right ventricle morphology and function, extracellular matrix fibrosis, and fibrosis-linked circulating microRNAs in dilated cardiomyopathy is unknown.
Are serum markers of extracellular matrix metabolism and circulating microRNAs associated with right ventricular morphological and functional parameters in patients with dilated cardiomyopathy?
Cross-Sectional (n=70)
No
Are serum markers of extracellular matrix metabolism and circulating microRNAs associated with right ventricular morphological and functional parameters in patients with dilated cardiomyopathy?
Extracellular matrix fibrosis markers and circulating microRNAs are not independently associated with right ventricular structural and functional abnormalities in patients with dilated cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Associations between ECM markers, microRNAs, and RV parameters in DCM are hypothesis-generating; prospective studies needed before clinical adoption.
BACKGROUND: The relationship between right ventricle (RV), extracellular matrix (ECM) fibrosis and fibrosis-linked, circulating microRNAs in dilated cardiomyopathy (DCM) is unknown. AIM: The aim of the study was to uncover the associations between serum markers of ECM metabolism and circulating microRNAs with RV morphological and functional parameters. METHODS: The study population consisted of 70 consecutive DCM patients (ejection fraction 24.4 ± ± 7.4%). Based on detailed echocardiographic assessment - 15 patients had normal RV, whereas 55 patients had RV dilatation (RVD) and/or RV systolic dysfunction (RVSD). Procollagens type I and III carboxy- and amino-terminal peptides, osteopontin (OPN), TGF1-b1, connective tissue growth factor (CTGF), MMP-2, MMP-9 and TIMP-1 were measured in serum as well as expression of miR-21, miR-26, miR-29, miR-30 and miR-133a. All patients underwent endomyocardial biopsy. RESULTS: Biopsy-proven fibrosis was evenly distributed in two groups. Serum levels of fibrosis markers did not differ between groups. OPN, CTGF, MMP-2, and TIMP-1 correlated with RV parameters. Only miR-133 a was differently expressed in both groups. MiR-21, miR-26, miR-30, and miR-133a cor-related with RV morphological but without functional parameters. Not a single marker of fibrosis was independently associated with RV. MiR-30 was associated with RV impairment in the logistic regression model adjusted for age, sex, body mass index, and disease duration; however, lost its significance in the more comprehensive model. CONCLUSIONS: Right ventricle structural and functional abnormalities are common in DCM. ECM fibrosis and serum markers are not associated with RV impairment. The prognostic value of studied microRNAs on RV is limited in DCM.
No takes yet. Share an insight, caveat, or question.
Rubiś et al. (2013) conducted a cross-sectional in Dilated cardiomyopathy (n=70). Right ventricular dilatation and/or systolic dysfunction vs. Normal right ventricular dimensions and systolic function was evaluated on Expression of circulating miR-133a [2^-DCq] (p=0.006). In patients with dilated cardiomyopathy, extracellular matrix fibrosis and serum fibrosis markers were not associated with right ventricular impairment, while only circulating miR-133a was significantly elevated in those with abnormal right ventricles.
Synapse has enriched 10 related papers. Consider them for comparative context: