Urinary 6-oxo prostaglandin Fl. in myocardial infarctionPlatelet activity, which may play a part in both atherogenesis and thrombosis, is inhibited by prostacyclin in vitro.We report a study of urinary 6-oxo prostaglandin F,z, one of the stable prostacyclin metabolites, in myocardial infarction. Patients, methods, and resultsEleven patients (mean age 57 9 years) with a diagnosis of myocardial infarction (classic history and electrocardiographic and enzyme changes) who denied having taken any drug for the previous 10 days gave an early morning two hour urine specimen after an overnight fast.Samples were collected on days 5 and 6, and eight to 10 weeks after myocardial infarction.Control samples were obtained under the same conditions from otherwise fit inpatients before operation who did not have the above diagnostic criteria.Family practitioners confirmed that no drug treatment was given after the patients' discharge from hospital.Prostaglandins were extracted from urine samples using octadecylsilyl silica C18 minicolumns and the prostanoid fraction eluted with methyl formate.
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Thompson et al. (1983) studied this question.
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