Key result
NPR-C blockade increases circulating CNP and potentiates its cardiovascular actions in dogs by reducing clearance.
Why the study?
No studies have defined the in vivo interaction of C-type natriuretic peptide (CNP) with the natriuretic peptide clearance receptor (NPR-C).
Does NPR-C blockade alter the clearance and cardiovascular effects of CNP in vivo?
Comparison
CNP infusion followed by NPR-C blockade with C-ANP-(4-23) at two doses vs baseline
Design
Preclinical intravenous infusion study
Authors
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NPR-C blockade potentiates CNP in dogs; hypothesis-generating for human translation, should not yet change practice.
Does NPR-C blockade alter the clearance and cardiovascular effects of CNP in vivo?
In vivo blockade of the natriuretic peptide clearance receptor reduces CNP clearance and potentiates its cardiovascular effects in a canine model.
Brandt et al. (1995) studied Anesthetized dogs (n=14). C-ANP-(4-23) (NPR-C blockade) vs. Baseline (CNP infusion alone) was evaluated on Total metabolic clearance rate (TMCR) and circulating CNP. In anesthetized dogs, NPR-C blockade with C-ANP-(4-23) increased circulating CNP, reduced total metabolic clearance rate, and potentiated the cardiovascular actions of CNP.