Key result
Head-up tilting produces no increase in urinary noradrenaline in older adults, reflecting age-related reflex alterations.
Why the study?
The study aimed to investigate the urinary excretion of noradrenaline response to tilting in elderly individuals to understand altered reflex circulatory adaptation in this age group.
Does head-up tilting increase urinary excretion of noradrenaline in healthy elderly persons?
Does head-up tilting increase urinary excretion of noradrenaline in healthy elderly persons?
Healthy elderly individuals do not show an increase in urinary noradrenaline excretion in response to head-up tilting, likely reflecting altered reflex circulatory adaptation with age.
Indicates age-related blunting of noradrenaline response to orthostasis; hypothesis-generating and should not yet change clinical practice.
Urinary excretion of noradrenaline was measured after 1 h in supine and 1 h tilted head‐up 70 in 8 healthy persons 71–75 years of age. The lack of increase in noradrenaline excretion in response to tilting found in the investigation is probably a normal consequence of an altered reflex circulatory adaptation in this age group.
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E Hedfors (1973) studied this question. Head-up tilting produced no increase in urinary noradrenaline excretion in healthy adults aged 71-75 years, likely reflecting normal age-related alterations in reflex circulatory adaptation.
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