Key result
Lovastatin reduces carotid intima-media thickness and increases LVEF versus standard therapy alone.
Why the study?
The effect of 12-month lovastatin therapy on vascular remodeling and left ventricular systolic and diastolic function in patients with stable ischemic heart disease and dyslipoproteinemia was studied.
Does lovastatin improve vascular remodeling and left ventricular function in patients with stable ischemic heart disease and dyslipoproteinemia?
RCT (n=84)
Randomized into 2 groups
Does lovastatin improve vascular remodeling and left ventricular function in patients with stable ischemic heart disease and dyslipoproteinemia?
A 12-month course of lovastatin therapy improves surrogate markers of vascular remodeling and left ventricular systolic function in patients with stable ischemic heart disease.
Supports lovastatin for remodeling in stable IHD; confirms surrogate benefits in this RCT.
Aim. To study effect of 12-month therapy with lovastatin on vascular remodeling, systolic and diastolic functions of left ventricle (LV). Material and methods . 84 patients (54,3±6,5 y.o.) with ischemic heart disease (IHD) and dislipoproteinemia were involved in the study. Patients were randomized into 2 groups. Patients of the 1st group (n=44) received lovastatin (20-60 mg daily) in addition to hypolipidemic diet and standard therapy. Patients of the 2nd group (n=39) were treated with diet and standard therapy only. Lipid spectrum and transaminase blood levels estimation, carotid duplex ultrasonography, echocardiography were performed initially and after 12 months of treatment. Results. Decrease of carotid intima-media thickness, delay of increasing of LV myocardium mass index, increase of LV ejection fraction was observed in 12 months of treatment in patients of the 1st group. There were not any changes of LV diastolic function in both groups. The conclusion . In patients with IHD and dislipoproteinemia 12 month lovastatin therapy prevents of vascular remodeling and improves LV systolic function.
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Kerimkulova et al. (2008) conducted an RCT in Ischemic heart disease and dislipoproteinemia (n=84). Lovastatin vs. Hypolipidemic diet and standard therapy only was evaluated on Vascular remodeling, systolic and diastolic functions of left ventricle. Lovastatin (20-60 mg daily) for 12 months decreased carotid intima-media thickness and increased left ventricular ejection fraction compared to standard therapy alone.
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