Key result
ACTN3 577XX genotype frequency links to global latitude, suggesting environmentally driven adaptive evolution.
Why the study?
The adaptive evolution of the ACTN3 577XX genotype in relation to environmental variables and global latitudinal gradients was hypothesized but not tested with methods accounting for evolutionary relatedness and gene flow.
Observational (n=3,351)
Effect estimate: slope 0.003 (95% CI 0.000-0.005)
p-value: p=0.06
The ACTN3 577XX genotype, which affects muscle metabolism, shows evidence of adaptive evolution associated with global latitudinal gradients.
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Hypothesis-generating for latitude-driven ACTN3 adaptation; leaves open any clinical or cardiometabolic relevance.
Friedlander et al. (2013) conducted an observational in Healthy general population (n=3,351). Global latitudinal gradient vs. null was evaluated on Relationship between ACTN3 577XX genotype frequency and absolute latitude (slope 0.003, 95% CI 0.000-0.005, p=0.06). The frequency of the ACTN3 577XX genotype in human populations covaries with the global latitudinal gradient (slope 0.003, p=0.06), suggesting adaptive evolution related to environmental variables.
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