Key result
Rotavirus infection accounts for ~79,000 acute gastroenteritis hospitalizations among children under six.
Why the study?
Rotavirus accounts for most severe acute gastroenteritis cases in children, but limited European countries have implemented rotavirus vaccination in pediatric programs.
Observational (n=334,982)
Yes
Rotavirus remains a consistent cause of pediatric hospitalizations in Italy, highlighting the ongoing burden of the disease.
Highlights substantial rotavirus hospitalization burden in young children; extends surveillance data but leaves open vaccination impact questions.
AGE severity is linked to etiology, and Rotavirus (RV) accounts for most of severe cases. In 2009 the World Health Organization recommended RV vaccination for all children. Worldwide a number of Countries implemented RV vaccination in their pediatric immunisation programmes, but only a limited number in Europe. This study was designed to estimate the proportion of RVGE among children aged <6 y who were diagnosed with AGE and admitted to hospitals in Italy during the years 2005-2012. A total of 334,982 hospital discharge forms were collected, being 79,344 hospitalizations associated with RV. The average hospitalization rate (HR) was 146/100,000 children for RVGE in primary diagnosis (PD) and 150/100,000 children for RVGE in secondary diagnosis (SD). Since 2008 the RVGE hospitalization figures and rates (HRs) in SD exceed those in PD. The majority of RVGE hospitalizations (33.67%) were reported among children aged ≤ 2 years. Despite some limitations due to the hospital discharge database (HDD) synthetic contents and low potential for clinical interpretation, the analysis of national HDD, including PD and SD, documents that RV still represents a consistent cause of pediatric hospitalizations in Italy.
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Mattei et al. (2015) conducted an observational in Acute gastroenteritis (n=334,982). Rotavirus infection was evaluated on Proportion of rotavirus gastroenteritis and hospitalization rate. Rotavirus infection accounted for 79,344 hospitalizations among children <6 years with acute gastroenteritis, with an average primary diagnosis rate of 146/100,000 children.
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